Could the deadly grip of TB drug therapy

Phase II clinical trials, chemotherapy, PaMZ — from a new TB drug candidate for PA 824, antibiotic moxifloxacin, and pyrazinamide existing TB drugs — people TB bacteria 99% within 14 days just killed.

This finding has been released of the 2012 International AIDS Conference, Washington DC, United States ( 7/23 ) this week from the Global Alliance for TB drug development.

Court — called NC-001 or the new combination 1 — held in 2 locations of the South Africa Republic period of two weeks. In the second test at site of eight in Brazil started NC-002 earlier this year, South Africa, Tanzania.

Not only successfully eradicated the regular TB, and can handle in four-month PaMZ form drug-resistant tuberculosis. These strains the current treatment of 18 – compliance with access to very expensive injections take 24 months, treatment include the very challenging.

President said to the Alliance, and the study authors SciDev.Net Melvin K spigelman,: "show" could have suited prescription drug-susceptible and multi-drug-resistant tuberculosis treatment research is.

"Took a whole new approach to TB drug development is this trial really exciting things. Dramatically reduces the time required to develop new anti-TB therapy together new combinations of testing in the early stages of development "and spigelman said.

PaMZ treatment over 8 weeks, NC-002 testing, patients are registered since March in the next study.

HIV-positive people new therapy will bring profits. To develop TB than HIV negative group is the biggest killer of people living with HIV/AIDS TB that is causing the TB bacteria-infected HIV-positive people is 34 times higher. It is hiv 1100000 people 82% TB, African development in 2010.

"[Are expected] new drug combinations are anti-to use other drugs such as Hiv medicine becomes easier" Andreas H radish, University of Stellenbosch, South Africa and judicial Chief Professor says.

Director on Mario Raviglione, Stop TB Partnership, WHO said: "that is confirmed is long in this therapy is [our available regimen is about 5 years for many years, estimated".

( MDR-TB ) drug susceptible and multi-drug-resistant TB simple can be safe, fast, easy and affordable prescription constitutes revolutionize TB care delivery method, Raviglione said.

TB is after almost 2 million people died every year and HIV with AIDS adults the world's second-biggest killer.